Does house matter in loosening of the bonds?

1
If the Loosening is occurring INTO the 12th house from fortune (or 6th or 8th) would that have any bearing on the interpretation?

Reason I ask is because the situation is such that the loosening is:

1. Happening in Leo (into light) on L3
2. The Sun is in the F1 house
3. The L1 and L2 lords can see the loosening's lord

However the lord on L1 is in detriment.

So my question is, does the fact that this loosening happens into the 12th place have any bearing on the interpretation?